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Yes, it is compatible with 3 ml cartridges from all major brands and supports 1 ml and 2.25 ml PFS
Furthermore, while MACE included mortality attributed specifically to cardiac causes, the broader definition of mortality within MAKE did not allow for precise attribution to renal causes due to the limitations of diagnostic coding
This pathway is well characterized in the broader growth-factor literature
With regards to specific outcomes such as HF, there has been heterogeneity in the results with both GLP-1RAs and DPP-4i