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Adults in the tirzepatide group had a mean 25.3% weight loss from baseline to 88 weeks, with 56.6% of the group achieving a 25% or higher weight reduction
United States Environmental Protection Agency
The most commonly reported side effects are nausea, upset stomach, and reduced appetite particularly when first starting the medication or when the dose increases
Water helps everything
After a one-month break, healthcare providers typically recommend restarting at a lower doseoften 2.5 mg weeklythen gradually re-escalating to minimize gastrointestinal side effects while restoring metabolic benefits
However, retatrutide is earlier in clinical development and not yet available
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