In our study, a J744.A1 mouse macrophage cell line was used to illuminate some mechanisms of interrelationship between hyperuricemia and its possible effect on the expression of oxidative stress-related genes
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This is significant because, if a single valid vector can be identified (see below for criteria), it demonstrates that somatic and affective symptoms have a common core and, hence, a shared pathophysiology [25]
Numerous studies showed that immune reactivity, inflammatory processes, and oxidative stress are actively involved in ALS pathogenesis (reviewed in [22, 23, 96, 102, 103])