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doi: 10.1016/j.psyneuen.2004.04.003 57 BiesselsGJDespaF

Glutathione lightens skin by inhibiting the tyrosinase enzyme, which is essential for melanin biosynthesis, and by shifting production from darker eumelanin to lighter pheomelanin

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Conversely, when fluid intake is inadequate or fluid losses are excessive, the kidneys conserve water by producing more concentrated urine, which appears darker yellow or amber