What are the main side effects of semaglutide
Clinical trials, including the SURMOUNT-5 study, demonstrate tirzepatides ability to achieve 13.7-20.2% weight loss in individuals with obesity but without type 2 diabetes, outperforming other GLP-1 receptor agonists in direct comparisons
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Semaglutide, liraglutide, and dulaglutide have been evaluated in completed cardiovascular outcomes trials that included renal outcomes, though OBrien notes that these were secondary end points in the studies
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