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Clinical data consistently shows tirzepatide produces greater average weight loss (15 to 22.5 percent vs 10 to 15 percent for semaglutide), but semaglutide is a proven, effective option with a longer track record and more global availability

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Withdrawal effects When GLP1s are stopped, patients may experience a range of physical symptoms

When name-brand GLP-1s such as Wegovy first started being prescribed for weight loss, in 2021, they were inaccessible for most Americans because of their steep cost and insurance providers limited coverage

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