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Early studies in obese individuals showed some reductions in body fat mass, but findings are not consistent across trials: In one clinical trial, AOD9604 did not demonstrate statistically significant weight loss compared to placebo, suggesting its fat-burning effects may be modest without lifestyle intervention (summary of trials)
Body-weight changes do not reveal long-term safety
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NNMT Inhibition Mechanisms Predicting Long-Term Effects NNMT (nicotinamide N-methyltransferase) is the enzyme that converts nicotinamide (a precursor to NAD+) into N1-methylnicotinamide, effectively removing it from the NAD+ salvage pathway
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In addition, vitamin B12 is needed to produce myelin and is important for axon and nerve development
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