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In a randomized crossover study of 14 patients with OSA, desipramine, for example, demonstrated a reduction in airway collapsibility that translated to a modest improvement in AHI in patients with minimal upper airway compensation at baseline [78, 79]

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For example, patients with systemic primary carnitine deficiency (SPCD) have a deficiency in carnitine due to a mutation in the plasma membrane sodium-dependent high affinity carnitine transporter (OCTN2) that enables cellular carnitine uptake in the heart, muscle, and kidney