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Le dosi inferiori servono alla titolazione iniziale, necessaria per ridurre gli effetti collaterali gastrointestinali nelle prime settimane di terapia (EMA, 2026)

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Dose escalation (titration): Gradually increasing your dose over several weeks to reduce side effects

Common side effects include upset stomach, nausea, vomiting, diarrhea, and constipation

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