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Rather than open access or blanket exclusions, leading employers are tying GLP-1 coverage to objective clinical criteria: BMI thresholds, documented comorbidities, and biometric screening data

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In a recent study, administration of exendin-4, a long-acting GLP-1RA, stimulated -cell proliferation in juvenile human islets by inducing gene expressions of calcineurin/nuclear factor of activated T cells (NFAT) signaling, a proliferating factor such as NFATC1, and a cell cycle regulator such as cyclin A1 [57]

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