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10.3390/life13041045 49 Sikorska-ZimnyK.BeneduceL
In vivo diabetic wound healing of G/D-CuP Male C57BL/6 mice were fed with a high-sugar, high-fat diet for four weeks, followed by intraperitoneal injection of premade streptozotocin (STZ) solution at a dose of 50 mg kg 1 daily for one week
Results showed: Significant increase in skin density and thickness Measurable reduction in fine line depth (up to 35% in some cohorts) Improved skin laxity and elasticity scores Enhanced skin moisture retention These effects are largely attributed to GHK-Cus ability to stimulate fibroblast activity the cells responsible for producing collagen type I and III, elastin, and hyaluronic acid
P = 0.12)
Prognostic Factors are: Tumor Size: Tumors larger than 5 cm at diagnosis are associated with significantly worse prognosis
Experimental and Clinical Endocrinology & Diabetes , 123 , 95-100
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