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Nrf2 can also affect intracellular iron distribution and storage by regulating the expression of ferredoxin and iron transporter proteins, thus indirectly affecting the sensitivity to ferroptosis (81)

Arginine is part of the urea cycle and can be rapidly cleaved to urea and ornithine by the arginase enzyme (Car1)

Acknowledgements This work was supported by CONICET (PUE 2016 22920160100010CO), FOCEM MERCOSUR (COF 03/11), ANPyCT (PICT-PRH 2017-4668 and PICT-PRH 2015-0022)

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Theoretically, it is believed to have the capability to lighten skin by inhibiting tyrosinase , one of the key enzymes in melanin production

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