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GIP is considered to work together with GLP-1 to have a greater effect than GIP alone

Additionally, patients often opt to discontinue this medication due to issues such as intolerance, loss of insurance coverage, affordability concerns, or pharmacy shortages

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In the SUSTAIN-6 trial , researchers looked at how semaglutide affected heart health in people with type 2 diabetes

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Even then, oral bioavailability remains low, around 0.4-1%, requiring much higher doses than injectable forms