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L-Carnitine is well-known for its role in energy production, helping the body convert fat into fuel, boosting endurance, and reducing fatigue
Cancer Res 1986
Diarrhea or Constipation: Gastrointestinal disturbances are frequently reported
Carnitine analogs produced by the gut microbiota can colocalize with carnitine in the white matter of the brain and inhibit carnitine-mediated FAO in cell culture models of mouse CNS white matter, affecting the hosts nervous system, which provides a new perspective for understanding the complexity of the gutbrain axis [252]
Plentiful clinical and experimental animal data indicate that IL-6 is highly induced in AILI and inhibiting IL-6 expression by multiple interventions can significantly alleviate the liver injury caused by APAP
Of note, albiglutide (TANZEUM) and tirzepatide (MOUNJARO) were not included in our study, given that albiglutide has been discontinued in the United States market since 26 July 2017, and tirzepatide was approved by the FDA in May 2022
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