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The STEP-1 follow-up data for Semaglutide showed that participants who discontinued the medication regained approximately two-thirds of their lost weight within one year without significant lifestyle intervention
Risks and Safety Considerations to Discuss With Your Doctor Key risks include cardiovascular effects from both agents, hormonal fluctuations due to rapid weight loss altering SHBG and free testosterone, gastrointestinal side effects, and the unknown combined safety profile of an unlicensed drug alongside a controlled hormone therapy
doi: 10.1001/JAMAINTERNMED.2022.0338 114 McCleanPLGaultVAHarriottPHlscherC
Topiramate, valproate, and propranolol were significantly linked to higher rates of adverse events than placebo
Ripoli, M
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