It consists of three amino acids, cysteine, glutamine, and glycine, and is responsible for the breakdown of toxic products, free radical destruction, and immune response
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Mox inhibits oxidative damage by upregulating NRF2-dependent antioxidant enzymes and producing GSH, which has been shown to be the main ATMs for lean AT (64, 138)
Of note, hemolysis is a fundamental feature of SCD and resulting excess hemin exposure 32 while hypoxia has been shown to induce the expression of fetal hemoglobin 33,34 , and promote the transition from expansion to differentiation during stress erythropoiesis 35
At the same time, it has a similar function to GPX7, which can increase the PDI activity of ER redox protein 1 (ERO1), promote the oxidative folding of endoplasmic reticulum proteins, and reduce oxidative stress (Raykhel et al., 2007)