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In humans, where C-cell GIP receptor expression appears to be lower, this effect may be minimal GIP and thyroid blood flow: Some preclinical data suggest GIP influences thyroid gland blood flow, which could theoretically affect hormone production and levothyroxine absorption in patients with remaining thyroid tissue No adverse thyroid effects in trials: In the SURMOUNT and SURPASS clinical trials, tirzepatide did not produce clinically significant changes in thyroid function tests in participants with normal thyroid function The presence of GIP receptors on thyroid tissue is an area of active research

Brunton SA, Mosenzon O, Wright EE Jr

In the STEP 1 and STEP 3 trials, participants with a mean BMI of 38 showed around 15% weight loss after 68 weeks treatment with 2.4mg semaglutide

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This medication will lower not only your fasting glucose level but also the post-meal blood sugar spikes because semaglutide releases insulin when there are high sugar levels in your body