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repletion reverses hematologic symptoms within days and neurologic sequelae over weeks, reflecting differential tissue turnover

The authors reported that intra-articular AOD-9604 injection in the rabbit osteoarthritis model produced macroscopic, histologic, and biomechanical evidence of cartilage preservation relative to untreated controls, with the combination of AOD-9604 plus hyaluronic acid yielding the most consistent chondroprotective effect [4]

Neither form causes toxicity in routine doses

Malabsorption due to digestive disorders, such as Crohns disease or celiac disease, can also lead to vitamin B12 deficiency