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Pre-treatment with the mitochondria-targeted antioxidant MitoQ can alleviate cisplatin-induced mitochondrial dysfunction, SIRT3 SUMOylation, and DHODH acetylation, providing a potential therapeutic approach for AKI[99]
Cell Metab 36(11):240218.e10 Liu C-Y, Wang M, Yu H-M, Han F-X, Wu Q-S, Cai X-J, Kurihara H et al (2020a) Ferroptosis is involved in alcohol-induced cell death in vivo and in vitro
However, one study has highlighted the anti-inflammatory property of soluble UA on activated monocytes, facilitated by the SLC2A9-mediated intracellular uptake of UA [50](Fig