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Moreover, Notch-1 is known to be strongly expressed in the perivascular area of synovial tissues and ROS can also induce the formation of vascular opacities by upregulating the expression of vascular endothelial growth factor (VEGF) and Notch-1 (53)

[25] [26] Orlistat remains a NICE-recommended option for weight loss support, available on prescription or over the counter (as Alli)

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In these cases, overdose can be fatal

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doi: 10.1111/joim.13750 Summary Keywords choline, acetylcholine (ACh), choline kinase (ChoK), phosphocholine, phosphatidylcholine (PC), inflammation, immune cells, immunity Citation Maia C, Fung CW and Sanchez-Lopez E (2025) Choline in immunity: a key regulator of immune cell activation and function