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Clinical Insight Karla K
10.1016/s0378-4274(01)00418-0 79 PolyakS
Factors that may contribute to reflux symptoms with semaglutide include: Prolonged gastric retention increasing intragastric pressure Nausea and retching, which can compromise sphincter integrity Changes in eating patterns and meal composition Pre-existing gastroesophageal reflux disease (GERD) that becomes symptomatic Clinical experience and patient reports suggest that some individuals do develop new-onset reflux symptoms or experience worsening of pre-existing GERD after initiating semaglutide therapy
Growth hormone secretion is diminished and tightly controlled in humans enriched for familial longevity
Additionally, a 7-year prospective study found that while NSW alone was not significantly associated with chronic pain or CRP levels, the combination of NSW and moderately elevated CRP was associated with an increased risk of chronic pain and pro-inflammatory background 150
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