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In recent years, several antagonists targeting STING palmitoylation have been developed to attenuate STING-mediated inflammation, such as C-170, H-151, nitrofatty acids (NO2-FAs), BPK-21, and 4-octyl itaconate, which block STING palmitoylation through covalent modification of Cys88/91 of SIING and inhibit its downstream type I interferon signaling (103105)

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