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Previous work has found that oncometabolites that suppress KGDD activity affect DNA repair and sensitivity to DNA-damaging agents 12,13,14,15,16,17,18

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To further confirm an NRF2-dependent effect of DMF, we compared the expression of those ferroptosis-related factors including CBS in sh NRF2 cells

These compound-specific effects could affect the way in which individual DPP4i are used therapeutically and potentially explain off-target adverse effects, such as hospitalization for heart failure, which is seen only with one DPP4i