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Solubility is pH-dependent in the way any folded protein's is

The typical dosing protocol involves 2-5 mg twice weekly for 4-6 weeks, followed by maintenance dosing

That said, hemoglobin also has some other lesser-known beneficial functions listed below

Mar 02 2016;21(3):303

Karyocytomegaly and/or Multinucleated Hepatocytes (Figures 65 and 66) Synonyms Karyocytomegaly, multinucleated hepatocytes, binucleated hepatocytes, karyomegaly, nuclear hypertrophy, hepatocytomegaly, polyploidy, anisonucleosis, anisokaryosis

Shaking generates shear stress and an air-liquid interface that promote peptide aggregation, and the resulting foam traps material out of solution