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GLP-1 activates specific neurons in the hypothalamus that signal satiety (fullness) whilst inhibiting neurons that drive hunger
So people that don't have it have a lower all-cause mortality
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As previously reported, the reduction of inflammation may be related to weight loss, that was significant in the different outcome trials, going from a 0.6-kg reduction at 12 weeks with Lixisenatide in ELIXA trial to 4.3 kg at 2 years with injectable semaglutide in SUSTAIN-6 trial [25, 26]
Additionally, gene ontology analysis detected accumulation of transcripts related to the three steps of protein synthesis (initiation, elongation, termination) in Gclc fl/fl MZB compared to Gclc fl/fl FoB (Supplementary Fig