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On the other hand, the enhanced formation of NETs coupled with their diminished clearance can trigger heightened inflammasome activation in macrophages, thereby intensifying the inflammatory response (81, 82)

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Total eNOS and activated eNOS were significantly lower in HUVECs treated with ET-1-generated EMVs compared with control EMVs

Geographical Distribution: Higher rates are seen in regions with temperate climates where fluctuations in the temperatures are common