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Conversely, although the medium containing Met was able to enhance the percentage of culture bovine oocytes developing into viable blastocysts, the global methylation was not altered by Met concentration ( While the maternal effects of RPM on embryonic development are well understood, the dietary paternal effects on sperm functionality and reproductive performance need further evaluation
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A separate regulatory submission for orforglipron in type 2 diabetes is planned for later this year
1c and Extended Data Fig
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