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(Diabetes, Obesity and Metabolism, 2025) showed that tirzepatide reduced total lean mass by 10.9% over 72 weeks

Persistent stressrelated cortisol elevation can worsen insulin resistance, making it easier to store carbohydrates as fat, especially around the abdominal area. In some patients, thyroid function or sex hormone imbalances (such as estrogen, progesterone, or testosterone shifts) may further slow metabolism or affect where fat is stored

on July 13, 2020)

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If dryness becomes severe, with cracking, bleeding, or extreme discomfort, reduce application frequency