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The Sortilin Related Receptor 1 (SORL1/SORLA) and its SNP are highly associated with the occurrence and development of late-onset AD and have been shown to affect the metabolism, trafficking, and processing of APP [211,212,213]

One study found that although the levels of B12 in the blood were normal in people with MS, the levels in their cerebrospinal fluid were lower than usual, although the reason for this difference was not clear