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It doesnt matter when
It's a complementary mechanism, not a standalone solution
Because it is constantly dealing with toxins, the liver requires a massive amount of antioxidant support
Sirtuins, particularly SIRT1 and SIRT3, protect cells from oxidative stress by increasing the activity of antioxidant enzymes, including superoxide dismutase 2 (SOD2) and CAT (127, 131, 132)
They typically fade as your body adjusts to the increased GH output
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