Here's what the clinical evidence shows: Semaglutide (Wegovy): In the STEP 4 trial, people taking the highest dose of semaglutide lost an average of 17.4% of their body weight over 68 weeks
It was made to chemically resemble a hormone that your body already makes called growth hormone-releasing hormone (GHRH)
Followup visits should evaluate not only glucose and weight, but also gastrointestinal tolerability, adherence, and psychosocial factors
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We now have access to meal plans, structured programs, and even food delivery
These include anorectic effects driven by previously discussed central modulation of satiety and reward pathways and peripheral activation of vagal afferents, delayed gastric emptying, anti-inflammatory properties, potential impact on energy expenditure and the ability to reduce ghrelin levels, which are inherently elevated in PWS ( 2 to 11.3 kg/m 2 ( 2 in 10/14 cases, and an HbA1c improvement in 19/23 cases, without reported serious side effects ( Semaglutide at a dose of 2.4 mg weekly is the first weekly long-acting GLP-1 RA approved for non-syndromic obesity treatment with a mean weight change of 14.9% in individuals with obesity without diabetes ( Our case series presents the long-term efficacy and safety of semaglutide treatment in patients with PWS without diabetes as well as semaglutide efficacy and safety in PWS previously treated with metabolic surgery