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In Japan, ALS patients received B12 shots of 25,000-50,000mcg (each shot equal to 25-50 pernicious anemia shots all at once), at first daily and then twice a week
Each form of B12 works along different biological pathways within the body
This dosing far exceeds the recommended dietary allowance for vitamin B12 but is appropriate for injection therapy and ensures adequate B12 status even in patients with increased requirements or absorption issues
''There have been no applications under the SAS for AOD-9604,'' the TGA spokeswoman confirmed on Thursday
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