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A total of five participants (mean age: 76+5 years

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Bile acids and the gut microbiota: metabolic interactions and impacts on disease

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doi: 10.1055/s-2008-1046759 155

These DAMPs are recognized by pattern recognition receptors (PRRs) such as TLR-2, TLR-4, and IL-1R on innate immune cells, leading to activation of inflammatory signaling pathways (e.g., NFB pathway) and upregulated expression of multiple genes with augmented transcription and release of proinflammatory cytokines (96)