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Statistical methods and details Mixed-model repeated-measures weight loss imputation A mixed model was run using SAS, including baseline weight, country, sex, prediabetes status, treatment, visit and the treatment-by-visit interaction as fixed effects, with a subject-level random effect
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Other notable adverse effects include: Injection site reactions (redness, itching, or discomfort) Fatigue Hypoglycemia (particularly when combined with insulin or sulfonylureas) Increased heart rate (mild elevation) Alopecia/hair loss (more common in weight management indication) Serious but less common risks include pancreatitis and gallbladder disease, which require prompt medical attention if symptoms develop
Expected Results and Timeline Patients undergoing semaglutide therapy can anticipate significant weight loss over time
