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The evidence converges

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Study protocol of the HYPER-LIV01 trial: a multicenter phase II, prospective and randomized study comparing simultaneous portal and hepatic vein embolization to portal vein embolization for hypertrophy of the future liver remnant before major hepatectomy for colo-rectal liver metastases

however, most phase III clinical studies are of insufficient duration and do not include enough study participants to effectively gauge long-term safety

Margulies KB, Anstrom KJ, Hernandez AF, et al