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This risk is higher in patients using tirzepatide in combination with insulin or sulfonylureas
According to a clinical primer published in the American Heart Association journal Circulation, semaglutide has been associated with lean mass making up a large share of total weight lost, by some trial estimates approaching 40 percent, and tirzepatide has shown a similar pattern at roughly a third of weight lost
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[6] Whether these combined effects meaningfully contribute to changes in skin physiology such as altered sensitivity or localised reactions remains speculative and has not been confirmed in published clinical trial data
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