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If your priority is no injection at all, ultrasound cavitation or fat freeze deserve a serious look
In cardiovascular outcome trials (CVOTs) such as Empagliflozin Cardiovascular Outcome Event Trial in Type 2 diabetes Mellitus Patients (EMPA-REG OUTCOME), CANagliflozin cardioVascular Assessment Study (CANVAS) and The Dapagliflozin Effect on Cardiovascular EventsThrombolysis in Myocardial Infarction 58 (DECLARE-TIMI 58) [6], they reduced the onset and progression of DKD, which was confirmed in the dedicated kidney trial The Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE), which showed a canagliflozin-induced risk reduction for ESKD in people with DKD by 32% [7]
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10.1016/0140-6736(91)90350-x Lancet
The importance of features was then ranked using the values of mean decrease accuracy. Finally, the model accuracy was measured according to the AUROC by using the ROCR package in R software [52]
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