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Front Cell Dev Biol 10:950623
It functions as a potent activator of tissue remodeling via upregulation of collagen I, III, and IV synthesis, elastin production, glycosaminoglycan accumulation, and metalloproteinase modulation
This energy expenditure component represents a mechanistic distinction from dual GLP-1/GIP agonists and has drawn significant attention in studies examining differential receptor contributions to energy balance
PMID 16423108
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