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Nonclinical Toxicology Carcinogenesis, Mutagenesis, Impairment Of Fertility A 2-year carcinogenicity study was conducted with tirzepatide in male and female rats at doses of 0.15, 0.50, and 1.5 mg/kg (0.1-, 0.4-, and 1-fold the MRHD of 15 mg once weekly based on AUC) administered by subcutaneous injection twice weekly

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Diabetes Care 26 , 881885 (2003)

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L-carnitine accumulates mainly in muscle, heart and lung tissue 8