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2 However, most of the current GLP-1 formulations have limitations that can affect patient adherence and treatment success, such as frequent injections, gastrointestinal side effects, inconsistent and low bioavailability, as well as high price
Boxed warning (applies to the drug class): In animal studies, GLP-1 receptor agonist medications caused thyroid tumors, including thyroid cancer
Steinbrenner and Brigelius-Floh, 2015), the brain and brain disease (Schweizer et al., 2004
Its not clear if this happens in humans and theres currently no evidence that it does
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Nevertheless, because of the geometry chosen, restriction to a 2D model for the epidermis and a continuous flux of incoming nutrient, the concentration may diverge in the simulation
