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76 Studies have shown that within various cell types, including vascular smooth muscle cells, endothelial cells, adipocytes, hepatocytes, pancreatic islet cells, and renal tubular cells, uric acid can activate NADPH oxidase, a crucial enzyme involved in the generation of reactive oxygen species
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The first PDZ domain of ZO-1 interacts with claudin proteins, the second domain interacts with other ZO proteins (ZO-1, -2 and -3), and the third domain interacts with JAM-A (Ulluwishewa et al., 2011)
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