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Over 18 months, about nine out of every 10,000 people in the GLP-1 group were diagnosed with ischemic optic neuropathy, compared with about six out of 10,000 in the GLT2 inhibitor group and about four out of 10,000 in the DPP4 inhibitor group

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Selective impairment of this carrier-mediated transport can contribute to selective vulnerability of tissues to specific toxins: for example, chronically ethanol-fed hepatocytes become selectively depleted of mitochondrial glutathione because of defective carrier-mediated transport, which makes the hepatocytes susceptible to damage by reactive oxygen species generated from the oxidative metabolism of ethanol (22)

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