Metabolic reprogramming driven by oncogenes allows cancer cells to maintain deregulated cell proliferation, withstand metabolic challenges that are associated with diminished oxygen and nutrients, maintain a dedifferentiated state through alterations in global patterns of gene expression, and corrupt the surrounding microenvironment to actively facilitate tumor growth and dissemination 16,17,18
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SASP (Senescence-Associated Secretory Phenotype) signaling begins declining as the source cells are eliminated Weeks 2-6: Tissue microenvironments improve as SASP-driven inflammation decreases
