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The interplay between HAS3-mediated HA synthesis and HYAL1-driven degradation further exemplifies intrinsic temporal control of ECM remodeling, providing a natural biological model that parallels HAGSH scaffold responsiveness [19]

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(2013) showed that in patients with active vitiligo (appearance of recent spots), there is a higher IFN- gene expression than in individuals without vitiligo or with stable vitiligo (individuals without the occurrence of new spots in the last six months)