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doi:10.1002/14651858.cd001520

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Preclinical rodent studies support effects on angiogenesis, endothelial function, and nitric-oxide-related signaling, though these effects are reproducible in animals but not yet validated in humans

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If you have chronic kidney disease, liver disease, or are taking medications that affect kidney or liver function, your provider may need to adjust the pyridoxine dose in your compound or monitor B6 levels more frequently