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Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element

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Structures were solved by molecular replacement using Phaser-MR and chain A of PDB 6U32 as the model

For instance, increased cysteine availability in plasma is related to an enhanced risk of breast cancer, particularly oestrogen receptor-positive (ER + ) and/or progesterone receptor-positive (PR + ) cancer and in combination with low folate availability in plasma