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doi:10.3389/fphar.2024.1461398 116

Physical symptoms include: Muscle aches, cramps, and joint pain Nausea, vomiting and diarrhea Excessive sweating and chills Runny nose and watery eyes Fever Goosebumps and skin crawling sensations Rapid heart rate Dilated pupils Psychological symptoms include: Intense anxiety and agitation Insomnia (often severe, lasting several days) Restlessness that feels impossible to sit with Depression that can set in as physical symptoms ease Cravings that may be stronger than anything youve felt before The physical symptoms are usually what people expect, but the psychological ones (especially the insomnia and anxiety) are often what makes withdrawal so hard to get through alone

Also it distinguishes the different types of active substances that exhibit different degrees of protection for the nervous system and summarizes the mechanism thereof