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Patients taking insulin or sulfonylureas should discuss potential dose reductions with their healthcare provider to reduce hypoglycemia risk during titration
TMAO can change the bile acid spectrum to accelerate the formation of aortic lesions in ApoE / mice, and further activate the nuclear receptors farnesoid-X-receptor (FXR) and small heterodimer partner (SHP), to reduce the expression of cholesterol 7-hydroxylase (Cyp7a1) to inhibit bile acid synthesis, thus accelerating the formation of atherosclerosis (82)
However it is NOT a substitute for injections
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May 30 2021;10(6)doi:10.3390/antiox10060874
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