[4] NAD + and SAM changes are not automatically harmful, and they should not be interpreted as toxicological findings by themselves
Vitamin B12 is water-soluble but stored in the liver, allowing high serum levels to persist after large supplemental doses
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Among them, mecobalamin is a coenzyme of N5-CH3-FH4 transmethylase (methionine synthase), which is involved in methionine-homocysteine metabolism (also known as the methionine cycle)
These effects can be troublesome and may require dose adjustments or treatment discontinuation