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This emphasis on long-term behavioral and psychological support is further underscored by a recent BMJ systematic review and meta-analysis showing rapid and clinically meaningful weight regain after discontinuation of weight-management medications, with regain occurring faster than after behavioral weight-management programmes [97]

doi:10.1016/j.freeradbiomed.2011.04.013

[25] It is important to note that because glutathione synthetase deficiency is so rare, it is poorly understood